systematic[sb] AND (orlistat) followed by hand searches
filter: systematic MeSH Terms: orlistat
doi: 10.1016/j.jash.2017.12.002. showed orlistat at any dose decreased BP by about 1 point on both systolic and diastolic in overweight or obese men
60 mg 3 x per day in a study (https://doi.org/10.1345/aph.1H234) of BMI 25 – 28 people was found to be marginally beneficial after 4 months over placebo; but had over 20% drop out rate, however imputed intention to treat analysis was done; study benefits could be halved to be conservative because of this. The study group showed 1kg extra total weight loss over placebo group, hence 0.5kg could be assumed to compensate for the bias.
In a MA of obese people it shows that there seems to be a lower total weight loss in non obese people versus obese people (BMI > 28 showing 1.5 – 4 kg total weight loss at 6 months versus above study of non-obese people showing only 0.5-1kg range) (https://www.ncbi.nlm.nih.gov/pubmed/22288431)