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Should I take anti-aging gene therapy? Klotho, sTGF-beta-2 and FGF21.

Oliver Zolman MD

· Longevity

https://www.pnas.org/content/116/47/23505

 

New paper out by George church last month, reviewed by aubrey de grey and Joao Pedro magalhaes, who has just recently made professor of Newcastle university!
 
Triple gene therapy in mice shows large effects on obesity, type 2 diabetes, heart failure and renal failure simultaneously - FGF21, alpha Klotho and soluble transforming growth factor-beta receptor 2, delivered by adeno associated viruses type 8 viruses which particularly target the liver.

The therapy increased blood FGF21 levels by 17x and alpha Klotho levels by 10x and decreased TGFbeta1 levels by 95%

 

Cue the early human adopters in Hawaii and South America...

 

Would be interesting to see this combined with epigenetic methylation rejuvenation therapy, myostatin inhibition, telomerase(?), calorie restriction optimal nutrition, senolytics, MHC exact-matched young exogenous haematopoietic stem cell therapy, rapamycin etc all at the same time in ~1 year old diverse wild type mice for a healthspan and lifespan study.

 

I wonder about generating antibodies against so many AAVs also I.e. Resistance to future AAV therapy - but there's several groups working on that (more advanced than just giving steroids to lower the immune system during therapy), can't remember what though.

 

Who should risk it? This would require a much larger analysis of the data... subscribe to be updated when I publish this soon.

https://www.pnas.org/content/116/47/23505

New paper out by George church last month, reviewed by aubrey de grey and Joao Pedro magalhaes, who has just recently made professor of Newcastle university!
 
Triple gene therapy in mice shows large effects on obesity, type 2 diabetes, heart failure and renal failure simultaneously - FGF21, alpha Klotho and soluble transforming growth factor-beta receptor 2, delivered by adeno associated viruses type 8 viruses which particularly target the liver.

The therapy increased blood FGF21 levels by 17x and alpha Klotho levels by 10x and decreased TGFbeta1 levels by 95%

Cue the early human adopters in Hawaii and South America...

Would be interesting to see this combined with epigenetic methylation rejuvenation therapy, myostatin inhibition, telomerase(?), calorie restriction optimal nutrition, senolytics, MHC exact-matched young exogenous haematopoietic stem cell therapy, rapamycin etc all at the same time in ~1 year old diverse wild type mice for a healthspan and lifespan study.

I wonder about generating antibodies against so many AAVs also I.e. Resistance to future AAV therapy - but there's several groups working on that (more advanced than just giving steroids to lower the immune system during therapy), can't remember what though.

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