Zolman Rejuvenation Leaderboards
Want to peer-review the biostatistics behind the Zolman Rejuvenation Leaderboards? Contact oliver@20one.consulting
Warning: major flaws of some markers in this leaderboard include insufficient N, unvalidated covariates, unclear outcome causality, synergy
This board scores you 1 point for each year younger you are in every marker that changes with age from MRI to blood tests.
7000 points = potentially irrefutable biostatistical evidence of being 20 years younger in all 70 organ types (5 markers on each organ avg. showing 20 years younger; 5*70*20 = 7000 Zolman Rejuvenation Points)
The tests must be proven to be measured via our externally valid methods and be submitted in non-fraudable format.
Multiple reads are required depending on the marker (to overcome 10 types of Coefficient of Variation).
Learn more beneath the table.
Over 1000 phenotypic/chronological based markers are included across MRI, ultrasound, devices, photography, biopsy, biosolids, biofluids, biogases. Each marker has different biostatistical and clinical quality and is scored out of 20 against Zolman Biological Age Marker (Z-BAM) Criteria (20 biostatistical criteria to assess the quality of a biological age marker).
There are leaderboards for whole body, organ systems, individual organs and markers leaderboards.
Zolman Rejuvenation Points (ZRPs) gain one point for each year a sufficiently validated marker (via peer-reviewed Zolman Biological Age Marker Criteria, Z-BAM) is below one’s chronological age.
ZRPs are the most method agnostic way of calculating rejuvenation due to it accumulating points indefinitely, with higher points scores having greater statistical certainty of rejuvenation across multiple organs.
There are hundreds of Zolman Clock markers across 78 organs that are eligible for scoring.
13000 ZRPs, which is roughly 8 markers per organ showing 20 years age reduction on average.
A new standard deviation and mortality morbidity outcome weighted scoring system is being implemented in the future.
The first person to achieve Level 99, may be the first person in history to robustly prove they have achieved LEV.
Contact us to compete
Anonymous Client #3
17% (10.6 years) younger on average across 4 PC clocks
Anonymous Client #4
8% (3 years) younger on average across 6 PC clocks
Leaderboards Analysis
See each person's Longevity Stack below
Oliver Zolman MD
Chronological age: 27 (in 2020)
Key biological age data:
Horvath-Levine PhenoAge: 10 (Jan 2019)
Body fat 7% (Oct 2020)
BMI 19 (Oct 2020)
PWV 5.9m/s (Oct 2020)
Whoop HRV 5 day 110 ms (Oct 2020)
How to submit your data for the leaderboard
What data to submit?
Submit PhenoAge as a bare minimum, provide further age reduction data to try and rank above people that have a PhenoAge younger than you. Most of your points come from organ biological age data.
1. PhenoAge Blood Panel
Use our PhenoAge calculator
For this test, you need to submit the following blood test results
FAQ
What's the minimum data to be listed?
Your PhenoAge Blood Panel test is taken into account, this predicts whole body biological age using cheap blood tests from 5 organs. We think its better than GrimAge, Horvath Clock or Aging.Ai as it has higher (95%) correlation with chronological age in 2 studies, is cheaper, easier to test, and provides insight across 5 organs using common markers used for decades already
How is equivalent biological age of a marker calculated?
Your score is identified on the y axis median (50th percentile) line, then followed down to the x axis of age, on the largest sample size graph available of the biomarkers' change with age in a normal population, ideally matched for gender and ethnicity. The difference between your x axis coordinate and your chronological age is then calculated.
How are biomarkers determined to be organ biological age markers?
These markers must be direct aging pathology markers, rather than contributing causes. E.g. high inflammation, high cholesterol or high liver enzymes are contributing causes, but don't measure organ biological age in the immune system, arteries or liver.
Instead of CRP or ESR, fibrinogen, MMP9 or IL-6, immune system PBMC and granulocyte short telomere length and loss of telomere length, white blood cell PhenoAge methylation age or GrimAge methylation age and beta-galactosidase stain or good fluoresence activated cell sorting data (FACS) for senescent cell status, or WBC function tests, bone marrow MRI, lymph node MRI, supported by WBC markers on FBC. These markers would also overlap with bone marrow biological age.
ABPM, CASP, ABPM-CASP, PWV, ABPI, MRA, aIMT, cIMT, AA diameter, CACS, CTA etc. would all measure arterial biological age, rather than cholesterol or triglycerides.
Rather than ALT, AST, GGT, ALP, liver biological age is measured by T1/T2/STIR/AMRA/DWI/SWI MRI, MRI elastography, strain or shear wave ultrasound elastography, ultrasound liver vessel parameters etc, supported slightly by albumin, INR, factor 5 and bilirubin blood levels (liver function tests), as well as specific markers of kupffer cell, hepatic stellate cell, liver sinusoidal endothelial cell and hepatocyte, cholangiocyte and hepatic lymphatic cell age.
How to submit data
What data is not acceptable
Your consent to publish your data
By submitting your data you agree to the following regards the use of your data, which overrides our standard terms and conditions and privacy policy where relevant
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