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  • WineSpan. For Lifespan.

    Alcohol Free.

    WineSpan is the only red wine supplement that has the exact same polyphenol profile as red wine. Allowing you to gain the benefits of wine without the alcohol.

     

    Developed by Oliver Zolman MD, only WineSpan polyphenols have been:

    • Associated with +5 years increased lifespan in men, +2 in women 
    • Proven to raise 3 antioxidant enzymes by 10%, 50% and 150% 
    • Proven to reduce the rise in oxidised LDL  100% after a meal
    • Proven to reduce the rise in cytotoxic MDA by 100% after a meal
    • In men at high heart disease risk: lowered blood pressure by 6 points
    Each 60 pill pack is designed to be equivalent to a large glass of French red wine per day, the same as 12 bottles of red wine per month, or 150 bottles per year. Saving over 4000 calories intake per month.
     
    Who is WineSpan for?
    People who do not want or cannot consume alcoholic or dealcoholised wine everyday, or as an add on supplement in people that consume alcoholic wine to enhance its benefits.
     
    See my analysis of 10 peer-reviewed studies, including 6 RCTs, that inspired me to create WineSpan. Click here.
     
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  • 500 different molecules

    One unique composition.

    WineSpan is the only molecularly identical red wine extract. Created through gentle evaporation of the ethanol from real French red wine, WineSpan leaves the unique molecular composition of red wine intact.

     

    The benefits of alcoholic red wine are thought to be majorly due to its polyphenol content, and not ethanol. This is because the same amount of ethanol from beer, spirits or white wine is not associated with the same lifespan benefit or randomised controlled trial evidence.

  • Tested and proven

    WineSpan is the only supplement that maintains the exact polyphenol composition of real French red wine.

    Dealcoholised red wine is backed by 3 human randomised controlled clinical trials (RCTs)

    Wine is associated in 3 Lifespan studies with 2-5 years increased lifespan, even in already very healthy people

    Increased 3 antioxidant defence systems by 10%, 50% and 150% in 7 days in those on a normal polyphenol diet. (RCT)

    Reduced the rise in toxic MDA by 100% if added to food before high temperature cooking (RCT)

    Reduced the rise in oxidised LDL cholesterol by 100% in diverse adult populations. White wine had no effect. (2 RCTs)

    Lowers blood pressure by 6 points and boosts nitric oxide in men age 55+ with 3 or more cardiovascular risk factors (RCT)

  • Developed by Oliver Zolman MD

    "I made WineSpan due to its potential benefits and it seemingly having no risks other than financial opportunity cost and sulphite allergies or intolerances. WineSpan can be used either as an addition to a glass of wine, or to allow alcohol abstainers to potentially gain the benefits of low dose wine consumption. Both myself and my parents take WineSpan as part of our longevity supplement protocol."

     

    Pricing of WineSpan?

    WineSpan is ethically priced with a low profit margin, and unless you are buying the cheapest wine possible, it is cheaper than buying wine in the UK.

     

    Given every pack of WineSpan is made from real French red wine, with the ethanol removed, and equivalent to 12.8 bottles of wine per pack, unfortunately it is not a cheap ~£5 a month supplement like many others. The price is currently £50 / $68 per bottle, equivalent to buying a bottle of French red wine for £3.90 (£4) or $5 USD or 4.5 EUR.

     

    The low profit margin pricing of WineSpan allows people of lower income families to access WineSpan. A common problem in the longevity supplement industry is the huge price hiking, where companies mark up the cost of ingredients to a 500% - 1000% profit margin and are deliberately mislead customers into thinking they cannot get the same product anywhere else, cheaper.

     

    Alternatives to WineSpan?

     

    Option 1: Non-alcoholic wine: WineSpan is available no where else, however you can buy dealcohlised bottles of red wine for a similar price to WineSpan in most UK or US supermarkets. The common disadvantage of these is that they are sweetened, so may boost blood sugar levels and have an odd taste from personal experience. These calories are "junk" sugar calories too as they are not from ethanol and is not ideal for a calorie restriction optimal nutrition diet (CRON).

     

    Option 2: Non-molecularly identical red wine polyphenols: There are many "red wine polyphenols" or "grape skin polyphenols" supplements on the market, however none of these contain the same polyphenols as fermented french red wine, the polyphenol molecules change a lot during the wine fermentation process and there is no evidence that these compounds have the same benefits as red wine polyphenols. This is not to say grape seed derived polyphenols have no benefit: for example a RCT showed that 200 mg a day of oligomeric proanthocyanidins (these are a subclass of flavonoids which are a subclass of polyphenols) from grape seed extract reversed atherosclerosis (plaques in the neck carotid artery on ultrasound scan) by 6% after 2 years in a broad population of BMI 24 men.

     

    Option 3: Doing nothing (taking no wine related supplements): You can still gain lifespan benefits from other longevity level 1 components, such as diet, exercise, BMI control, calorie restriction optimal nutrition and smoking cessation or alcohol reduction & drinking alcoholic red wine; however the wine's lifespan benefit might stack on top of all of these.

     

    Option 4: Drinking red wine: Drinking red wine will provide at least the same benefits of WineSpan (and maybe more for some people due to the potential theoretical (but unproven) benefits of ethanol itself), but comes with the following downsides in some people

    1. 4000 calories per month extra (1 medium 175 mL glass of red wine per day is 140 calories. 140 x 30 days a month = 4200 calories)
    2. Cognitive changes that are unwanted in some people 
    3. Religious incompatibility in some religions 
    4. Requirement to store 8 bottles of wine per month, taking up space
    5. Not compatible with certain medications
    6. Can be more expensive (if not buying the cheapest wine)
    7. Requires accurate dosing of wine to not have too much
    8. Non-sulphite wine component intolerances, such as tannins, causing headaches etc (note WineSpan contains Sulphites as it is hard to extract these without affecting the polyphenol composition)
    9. Active liver or kidney disease may contraindicate alcohol
    10. Hard to get around it 'tasting bad' for some people
    11. Requires enhanced dental cleaning in some people to stop stains
    12. Even a small or medium glass of red wine may disrupt sleep in some people even when taken with dinner, due to ethanol content
    13. Some have ethanol dehydrogenase enzyme genetic variants that mean they metabolise ethanol very slowly and cannot even drink small amounts, even after repeat exposure
    14. In people with alcohol excessive use disorders or predispositions, even a small glass of red wine per day can be contraindicated  
    Option 5: Winespan
    WineSpan is based on the 10 studies below on this page.
     
    The product is designed for each serving to
     
    1) exceed an above average polyphenol content glass of large red wine (>450 mg) and
     
    2) reliably match or exceed all doses of red wine polyphenols used in red wine polyphenol randomised controlled trials (RCTs) (>540 mg).
     
    The average polyphenol content of red wine is 1800 mg/L as shown in Pubmed Reference.
  • The 10 studies that inspired me to create WineSpan

    Lifespan study #1

    Life expectancy was 5 years longer in men who consumed 0.5-1.5 units wine a day, but not beer or spirits

     

    Even after adjusting for 18 confounding factors. (Link to study)

     

    Population: 1373 Dutch men followed for 40 years.

     

    Intervention: 0.5-1.5 units wine per day

     

    Control group: No alcohol, or beer or spirits or more than 2 units wine per day

     

    Confounders adjusted for: Former drinking, energy intake without alcohol, the number of cigarettes smoked, cigarette smoking duration, cigar or pipe smoking, intake of vegetables, fruit, fish, saturated and trans fatty acids, body mass index, prevalence of myocardial infarction, stroke, diabetes mellitus and cancer, baseline socioeconomic status and total alcohol intake

     

    Critique: Part of the effect size may be due to the control group including former drinkers, however the intervention group was adjusted for former drinking status.

     

    Author's quote: "For long-term wine consumers, consuming on average less than half a glass of wine per day, life expectancy at age 50 was about 5 years longer compared with no alcohol users"

     

    Relevance to WineSpan: Here we can see the benefit of alcohol drinking is likely not just due to ethanol, the alcohol molecule. Rather it is the unique polyphenol profile of wine that may provides benefits, and only WineSpan has the some molecular profile as real wine.

    Lifespan study #2

    Low dose alcohol intake is associated with +2 years lifespan in men and women, even in the top 5% healthiest people

     

    A 34 year long, 14 confounder adjusted observational study, adjusted for extensive dietary, BMI, exercise and smoking factors (Link)

     

    Population: 133,000 USA men and women from the NHANES cohort, were followed for 34 years from age 47 on average. They were mostly caucasian healthcare professionals.

     

    Observations: Every 2 - 4 years, for 34 years (12 readings per person for each variable on average) alcohol intake, BMI, weekly exercise hours, healthy diet score and smoking status were tracked.

     

    Outcomes: Even in people who exercised 6+ hours a week, who had the top 20% healthiest diet, were never smokers and who had optimal BMI, 0.5-1.5 units a day alcohol consumption taken for 34 years from age 50 onwards was associated with 2 years increased lifespan in men and women. Over 10 million Americans were followed for 34 years on average in this study.

     

    For the healthiest men that have a BMI 18.5-22.5, exercise 6+ hours a week, don't smoke and have a top 20% healthy diet, 0.5-1.5 units a day alcohol consumption may add another 6 years to average lifespan, giving 8 years total.

     

    Confounder Adjustments: The results were adjusted for 14 things to check that these were not responsible for the benefits of the specific lifestyle behaviours: alcohol intake, exercise, BMI, smoking status, weekly exercise hours, age; sex; ethnicity; current multivitamin use; current aspirin use; family history of diabetes mellitus, myocardial infarction, or cancer; and menopausal status and hormone use (women only).

     

    Relevance to WineSpan: Here we can see good epidemiological evidence that low dose alcohol intake of up to 1.5 units a day is healthier than zero intake. Whilst this does not provide specific evidence for WineSpan (whereas the other 7 studies in this analysis do) it is an important study to include to strengthen the case for the benefits of low dose alcohol and polyphenol consumption.

    Lifespan study #3

    Wine, not beer or spirits, may reduce risk of death from all causes the most. (Link to Meta Analysis of Observational Studies)

    Population: 6 observational studies of 57,000 people, and over 10,000 deaths, followed on average for 25 years.

     

    Intervention: 100 mL of wine per day

     

    Control group: No wine consumption, any beer or spirits consumption or over 400 mL wine consumption per day.

     

    Outcomes: 95% chance of at least a 14% reduction in death from any cause, 50% chance of a 25% reduction, and 5% chance of a 34% reduction versus no wine consumption or more wine consumption.

     

    Confounder adjusted for: Age, smoking, BMI (study 19), sex, age, expected level of need, total alcohol consumption (study 22), Consumption of other beverage types, smoking, BMI, physical activity, cohabitation, income and education (study 26), age (study 31), Former drinking, energy intake without alcohol, number of cigarettes smoked, cigarette smoking duration, cigar or pipe smoking, intake of vegetables, fruit, fish, saturated and trans fatty acids, body mass index, prevalence of AMI, stroke, diabetes mellitus and cancer, baseline socioeconomic status and total alcohol intake (study 32)

     

    Relevance to WineSpan: Here we can see the benefit of alcohol drinking is likely not just due to ethanol, the alcohol molecule. Rather it is the unique polyphenol profile of wine that may provides benefits, and only WineSpan has the some molecular profile as real wine.

    Lifespan study #4

    For women drinking low dose wine, but not spirits or beer, they were 21% - 68% more likely to reach age 90, even after adjusting for 16 potential confounding factors (Link to observational study)

     

    Relevance to WineSpan: Here we can see the benefit of alcohol drinking is likely not just due to ethanol, the alcohol molecule. Rather it is the unique polyphenol profile of wine that may provides benefits, and only WineSpan has the some molecular profile as real wine.

    Clinical trial #1: Dealcoholised red wine

    Increases 3 antioxidant defence systems by 10%, 50% and 150%

    A randomised controlled trial (Link)

    Population: Healthy people age 28 on average (25 - 40) who had eaten a low polyphenol diet for 2 days prior to starting the intervention, and stopped any vitamin, mineral, drug or antibiotics for 4 weeks before.

     

    Intervention: Drinking 300 mL dealcoholised red wine at dinner each day. This is equivalent to 540 mg* red wine polyphenols (as there are around 180 mg of polyphenols in 100 mL of commercial red wine (Reference)).

     

    *Each WineSpan capsule contains 320mg French red wine polyphenols. The recommended serving size is 1 - 2 capsules WineSpan per day, bringing the daily intake to around 640 mg polyphenols - that's 100 mg more than was used in this study.

     

    Control group: Each person was randomised to drink dealcoholised red wine for 1 week or follow a low polyphenol diet for 1 week and then crossed over to the other intervention to act as their own control group.


    Outcomes: Adjusted for 2 day washout period of low polyphenol diet:

    • Glutathione reductase activity increased from 44.5 to 50 U/L a 12% increase
    • Catalase activity increased from 10.7 to 16 nM/min/ml, a 50% increase
    • SOD (superoxide dismutase) activity increased from 58 to 182 U/mL of RBC, a 150% increase
    Relevance to WineSpan: Here we can see it is not the alcohol component of red wine that is providing the benefits, additionally this trial of dealcoholised red wine will have used near identical polyphenol content to WineSpan - taking into account the minor variation in polyphenol profile between red wines.

    Clinical trial #2: Dealcoholised red wine

    Lowers systolic and diastolic blood pressure by 6 and 2 points and increases nitric oxide by 4 uM in people at high cardiovascular risk (Link to RCT)

     

    Population: Sixty-seven 55-75 year old men, who had type 2 diabetes or 3 or more cardiovascular risk factors.

     

    Intervention: 300 mL dealcoholised red wine per day, equivalent to less than 1 serving of WineSpan.

     

    Control group: Alcoholic red wine or gin were given to the control groups.

     

    Outcomes: Only dealcoholised red wine:

    • Lowered systolic blood pressure by 6 points 
    • Lowered diastolic blood pressure by 2 points
    • Increased nitric oxide by 4 umol/L
      Relevance to WineSpan: Here we can see it is not the alcohol component of red wine that is providing the benefits, additionally this trial of dealcoholised red wine will have used near identical polyphenol content to WineSpan - taking into account the minor variation in polyphenol profile between red wines.

      Clinical Trial #3: Red Wine powder plus alcoholic red wine

      Prevented 100% of the absorption of cytotoxic lipid peroxidation products from food, known as MDA (malondialdehyde). (Link to RCT)

      Population:

       

      Intervention: Adding 200 mg (around half a WineSpan pill) molecularly identical red wine polyphenols powder to a meal before cooking + drinking a 200 mL (Medium-Large) glass of red wine with a meal.

       

      Control group A: No red wine intake with meal and no red wine polyphenols used

       

      Control group B: Drinking a glass of wine only with the meal, no red wine polyphenols used.

       

      Outcomes: Reduced plasma MDA levels after eating by 100% on average.

       

      Interpretation: Ingesting a WineSpan pill with a meal theoretically works in the same way as adding it to food during the cooking process - by stopping absorption of any created lipid peroxides in the food. If you don't want to drink red wine with the meal either, its likely that just taking the WineSpan pill with the meal alone will reduce MDA a lot. MDA in the body is cytotoxic, i.e. it kills cells and accelerates the aging process.

        Relevance to WineSpan: Here we can see it is not the alcohol component of red wine that is necessary for the benefits, and that adding the powder form enhances the benefits of alcoholic red wine.
         
        Additionally this trial of dealcoholised red wine will have used near identical polyphenol content to WineSpan - taking into account the minor variation in polyphenol profile between red wines.

        Clinical Trial #4: Alcoholic red wine

        Alcoholic red wine prevented 100% of the rise in dangerous oxidised LDL cholesterol in a broad range of people. This is unlikely to be due to the alcohol content, as White wine showed 0% prevention in the rise of oxLDL.

        250 mL of red wine with a meal prevented 100% of the increase in dangerous oxidised LDL, a RCT in healthy people, that don't consume more than 2 cups of flavonoid-rich beverages, such as tea, herb tea, coffee, cocoa, and fruit juice per day (Link to RCT #1)

         

        Red wine prevented 100% of the increase in dangerous oxidised LDL in all adults after a Mediterranean or high fat meal, and reduced oxidised LDL below baseline - white wine had no effect. Participants were a broad range of healthy adults on a normal polyphenol diet (Link to RCT #2)

          Relevance to WineSpan: Here we can see it is not the alcohol component of white wine NOR the polyphenols of white wine that is providing the benefits. Hence it is red wine that is optimal for this marker, not white wine.
           
          Additionally this trial of red wine will have used near identical polyphenol content to WineSpan - taking into account the minor variation in polyphenol profile between red wines.

          Randomised clinical trials on alcoholic red wine outperforming white wine

          Clinical trial #5: Red wine increases protective glutathione peroxidase gene expression by 10x when taken with a Mediterranean or high fat meal, whilst white wine has no effect (Link to RCT)

           

          Clinical trial #6: Red wine, but not white wine, raised good cholesterol (HDL-C) by 5 mg/dL in women (but not men), and Lp(a) by 0.1g/L (Link to RCT)

           

          Relevance to WineSpan: Here we can see it is not the alcohol component of white wine NOR the polyphenols of white wine that is providing the benefits. Hence it is red wine that is optimal for this marker, not white wine.
           
          Additionally this trial of red wine will have used near identical polyphenol content to WineSpan - taking into account the minor variation in polyphenol profile between red wines.

          However, one RCT has shown white wine to reduce inflammation (CRP blood test) in healthy people

          White wine reduced inflammation in healthy volunteers (CRP reduced from 0.26 md/dL to 0.19 mg/dL) and even more in people with chronic kidney disease (0.53 mg/dL to 0.34 mg/dL) (Link to RCT)

          *Red wine was not tested in this study

        • FAQ

          Is there anything I should notice once I start taking WineSpan?​

          WineSpan is designed to work beneath the surface, so its primary purpose is not to deliver surface-level results. Taking WineSpan is an investment in your long-term health of your cells, and you may not feel different despite the improvements happening inside your body. Everyone’s physiology is unique and results vary from person to person.

          Can't the potential benefits of alcoholic drinks come from the ethanol itself?

          Whilst ethanol may have some benefits in preventing blood clots (platelet aggregation), there is not much evidence for ethanol benefitting much else, and rather to the contrary. This would not fit with our current understanding of aging biology, as to yield a 2 year lifespan extension ethanol would be needing to have more evidence on aging biomarkers.

           

          Polyphenols, particularly red wine polyphenols, on the other hand have have a wealth of evidence including randomised controlled trials, that fits in with our understanding of improving biomarkers that are slowing the aging process, such as oxLDL, MDA, blood pressure and antioxidant enzymes.

          Why red not white or rose?

          When it comes to wine, red wine has around 6 - 7.5x higher polyphenol content per 100 mL than white wine (PubMed Reference 1) (PubMed Reference 2) and 5 times higher than rose wine (PubMed Reference).

          How is each serve equivalent to a large glass of French Wine? And how did you choose the dose of polyphenols per serving?

          WineSpan is based on the 10 studies on this page. The product is designed for each serving to

           

          1) exceed an above average polyphenol content glass of large red wine (>450 mg) as from the observational studies and

           

          2) reliably match or exceed all doses of red wine polyphenols used in red wine polyphenol randomised controlled trials (RCTs) (>540 mg).

           

          The average polyphenol content of red wine is 1800 mg/L as shown in PubMed Reference.

          How long should I take it for?

          WineSpan is designed to be taken for life. Either by itself or in addition to 0.5 - 1.5 units alcohol per day on average (recommended under 6 units total per day maximum to avoid binge drinking).

           

          The lifespan benefits of low dose alcohol intake in the prospective observational studies typically take 5+ years to start showing. In order for WineSpan to achieve its maximal benefit it should be taken for as young as possible.

          When do I take it?

          WineSpan should be taken with a meal, ideally supper, to replicate when red wine is normally taken.

           

          Alternatively part or all of the capsule can be emptied into the food before cooking, as a flavouring and to protect the food from molecular damage in the cooking process.

          Why are SOD, CAT and GPr important?

          CAT (Catalase)
          Grey hair is thought to be caused in part by a build up of hydrogen peroxide due to lack of catalase enzyme (catalase removes hydrogen peroxide). In a Chinese human grey hair study, in which Chinese men under age 25 experienced grey hair, it was found their hair catalase enzyme levels 30 x lower than in pigmented hair (Human Study). This association was also found in another human grey hair study (Human Study). However, catalase enhancers or red wine polyphenols have not been tested for grey hair repigmentation yet.
           
          Catalase when targeted to the mitochondria specifically slowed aging by 10% in wild type mice. It is not known if red wine polyphenols increase mitochondrial catalase levels, or just catalase in the nucleus, extracellular spaces or peroxisomes (these are the other common places where catalase resides). (Wild type mouse lifespan study).
           
          Low catalase levels are associated with causing sarcopenia, low muscle mass and strength in the elderly. (Rat Study)
           
          Catalase brain cell levels decline by 60% in age 65 human equivalent mice and rats, from age 18 human equivalent mice and rats. (Rat and mouse study). Arterial catalase activity levels in wild type mice were 50% lower at age 65 equivalent versus teenage years (Wild type mouse study)
           
          SOD (Superoxide dismutase)
          The role of SOD activity in aging is not clear. SOD is made up of SOD 1, 2 and 3. SOD1 mutations or dysfunctions that reduce its efficacy are linked to both familial and sporadic onset ALS (Lou Gherig's or Steven Hawking's disease). SOD enzyme activity is upregulated by the body naturally during times of stress - such as in late night or shift work, Alzheimer's disease or sarcopenia (Rat Study), but one theory is that upregulating it in advance of experiencing the stress allows the body to respond more quickly and achieve better outcomes. We could not find good human evidence of associated of RBC SOD activity levels and outcomes.
           
          Scientists that slowed the aging process in wild type mice using mitochondrial catalase hypothesise that enhancing SOD1 and 2, as well as catalase will enhance lifespan even more than enhancing catalase alone (Wild type mouse lifespan study).

          How did you calculate the adjusted antioxidant level gains to take into account the 2 day low polyphenol diet washout period?

          Compared to the baseline levels (2 days after starting a low polyphenol diet)

          • Glutathione reductase activity increased from 40 to 50 U/L, a 25% increase
          • Catalase activity increased from 9 to 16 nM/min/mL, an 80% increase
          • SOD (Superoxide dismutase) activity increased from 58 to 182 U/mL of RBC, over a 215% increase (more than tripled)
          • Lipids, liver markers, glutathione peroxidase, urate and GSH/GSSG ratio were unchanged
          As these antioxidant levels will drop consistently during the 2 days on a low polyphenol diet, we can take the average daily drop during the 7 study days and divide this by 2/7 to estimate how much the levels would have dropped in the first 2 days. We then compare this predicted baseline level in the control group to the results of the dealcoholised red wine group. This represents a worst case scenario, as half the control group will have been taking red wine the week before so may have elevated levels compared to controls that had just started the study 2 days previously. This would yield the following adjusted results
           
          We can be quite sure sure that it is the dealcoholised red wine causing this increase in antioxidant enzyme levels as the participants likely did not consume any other polyphenol rich foods. As the dealcoholised red wine increases the antioxidant levels above the baseline levels that were on the normal polyphenol diet levels, we can be somewhat sure that it will boost antioxidant levels in people already on a normal polyphenol diet.

          Does wine cause cancer?

          The risk of cancer from wine is due to the alcohol component not the polyphenols. So non-alcoholic beverages or WineSpan will carry no risk.

           

          In terms of alcoholic beverages, beer and spirits may increase risk at any level, however in low doses, wine may in fact reduce the risk of cancer more than not drinking at all. This is regards the risk of developing cancer in the first place and does not apply to post-cancer-diagnosis related outcomes such as cancer survival after diagnosis.

           

          To quote from one study "the data show that the carcinogenic effect of alcohol may be restricted to beer and spirits and may not be present in wine".

           

          50-90 mL wine/day may lower risk of breast cancer

          A meta-analysis of 26 observational studies all with multiple confounder adjustment found a 13% - 16% (95% confidence interval) reduction in breast cancer risk for those that drank 50 mL of wine per day, up to 90 mL of wine per day provided 95% chance of no increase risk of breast cancer. (Link to Meta Analysis)

           

          Wine likely has no effect on colorectal cancer risk

          A meta-analysis of 17 studies with 11000 colorectal cancer cases found no association for wine intake at any level (2019 meta analysis of cohort and case control studies)

           

          Red wine but not white wine might lower lung cancer risk

          A small case control study found red wine may reduce risk of lung cancer by at least 1%-2% per glass, whilst white wine may increase by 1%, there was no association with beer or spirits. These results were adjusted for cigarette pack count history. (Case control study)

           

          Wine likely no effect on oral cancer risk

          1-2 drinks of wine per day was associated with at least 25% increased risk of oral cancer diagnosis, however it is not clear how much beer these people drank and it was not adjusted for oral cancer causing HPV infection. I.e. they could have just been drinking a lot of beer, or had a higher incidence of oral HPV infection than the control group (Case control study)

           

          In one study with unclear 95% confidence intervals the median risk reduction in oral cancer was 45% in those drinking red wine of an unclear dose (Case control study)

           

          Up to 21 drinks of wine per week was not associated with upper digestive tract cancer and may reduce risk (Case control study), 1-2 drinks wine a day had no effect on oral cancer risk (Case control study), any amount of wine was not associated with oral cancer risk in the absence of other beer or spirit intake (Case control study)

          How does WineSpan differ from resveratrol?

          Resveratrol is just one polyphenol out of the 500+ polyphenols that naturally occur in red wine. Typically from 270 mg red wine polyphenols 0.1-1 mg of this is resveratrol. Hence is it around 0.1% to 0.3% of the polyphenols in red wine.

           

          The use of resveratrol does not seem evidence-based due to failure to provide clinically significant effect in all randomised clinical studies, non-randomised studies of interventions, pre-clinical lifespan studies and human epidemiological data.

        • Select your WineSpan Plan

          Alcohol free - Vegan - Vegetarian - 1 calorie per pill

          Molecularly identical polyphenols verified - Heavy metal tested - Bacterial contaminant tested

          Each pack of WineSpan pills provides polyphenols equivalent to

          • 1 large glass of French red wine per day

          • Over 12 bottles of French red wine per month

          • Reduces your calorie intake by 4000 calories per month

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          • These terms and conditions apply to the use of any of the Services or documents received from 20one Consulting and also to any websites in the www.oliverzolman.com domains; the “20one Content”. Where indicated, additional terms and conditions apply to specific Services or websites only.
          
          • Content may be accessible by the general public globally. Members of the general public may also find them of interest and may use them to inform discussions with practitioners or researchers and those who make decisions about the funding of care/ research. 
          
          • If you are an individual who chooses to access 20one Content, you should not rely on that information as professional medical advice or use it to replace any relationship with your doctor or other qualified healthcare or social care professional. For medical concerns, including decisions about medications and other treatments, individuals should always consult their doctor or, in serious cases, seek immediate assistance from emergency personnel. Individuals with any type of medical condition are specifically cautioned to seek professional medical advice before beginning any sort of health treatment. If you are a member of the public, 20one recommends that you should evaluate 20one Content together with your physician or another qualified healthcare or social care professional. 
          
          • In relation to the mention of any scientific evidence and the interpretation of it: It is in the nature of scientific debate that not all authors will agree on all matters. Further, published papers may be in error, or superseded by later research. It is the user's sole responsibility to assess all evidence and to reach a decision informed by it. 
          
          • Our 20one Content and staff do not provide medical advice. Our staff do not perform the practice of medicine through 20one.
          
          • The contents of 20one Content are scientific information only and is not intended to diagnose, treat, cure or prevent any disease, disorder, injury or to act as triage.
          
          • The 20one Content, such as text, graphics, images, information obtained from our licensors, and other material contained are for informational, educational and research purposes only
          
          • If staff whom 1) hold primary medical qualifications (medical degrees) – and who may or may not be registered and or licensed to practice medicine in any jurisdiction globally -  or 2) hold any statutory healthcare professional role as relevant to their jurisdiction; have contributed to the development of any 20one Content they are NOT acting in their capacity as any of the listed statutory healthcare professionals in the UK or statutory healthcare professionals as relevant to their international jurisdiction, only in their capacity as non-statutory scientific and health research consultants. 
          
          • You must not rely on the information supplied from 20one Content as an alternative to medical advice from your doctor or other professional healthcare provider.   
          
          • If you have any specific questions about any medical matter you should consult your doctor or other professional healthcare provider.
          
          • If you think you may be suffering from any medical condition you should seek immediate medical attention.  
          
          • You should never delay seeking medical advice, disregard medical advice, or discontinue medical treatment because of information included in our Services or websites
          
          • Reliance on any information from 20one Content is at your own risk. 20one is not responsible or liable for any advice, course of treatment, diagnosis, drug and device application or other information, services, or products that you obtain as a result of 20one Content we provide.
          
          • I am aware that I am strongly encouraged to discuss any 20one Content with my licensed doctor. We recommend you always consult an appropriate healthcare professional for advice on your specific circumstances and situation
          
          • You acknowledge and agree that 20one Content is not a substitute for actual medical diagnosis, treatment or consultation with a doctor, and that 20one Content does not constitute medical advice and/or recommendations for medical treatment regarding any aspect of your health, medicine intake, nutrition or lifestyle. 
          
          • 20one Consulting and Staff have made reasonable effort to ensure the accuracy of data or information used in 20one Consulting Deliverables. However, 20one Consulting Staff, Advisors and Associates cannot accept responsibility for any errors or omission, or for any consequences from application of the data or information provided through 20one Consulting Deliverables, and make no warranty, expressed or implied, with respect to the currency, completeness or accuracy of the data and information within 20one Consulting Deliverables.
          
          • No guarantee can be made whether developed Deliverables will meet your expectations for Deliverables recommendations or content, or that you will be able to implement these Deliverables as an organisation, a clinician or as an individual wanting a clinician to use such Deliverables.
           
          Terms & Conditions
           
          The Services provided by 20one Consulting Limited are available subject to the following terms and conditions.
          
          Context
           
          1.	The Services provided and associated resources such as websites or external documents are owned and operated by 20one Consulting Limited (“20one Consulting”) a private limited company registered in England and Wales, with company number 10299987. ("20one Consulting", "us", "our" or "we").
          
          2.	Our Services are only intended for English language fluent adults (age 18+), and not for children
          
          3.	These terms and conditions apply to the use of any of the Services, documents, websites in the www.20one.consulting or www.betterguidance.com, www.longevity.school or www.drzolman.com domains; the “20one websites”. Where indicated, additional terms and conditions apply to specific Services or websites only.
          
          4.	The Services and 20one websites provide information about 20one’s work, including its recommendations on the use of health technologies, guidelines on the research, management and treatment of particular conditions and its ongoing development of such recommendations and guidelines and other information.
          
          5.	Users must only use the Services and websites for purposes consistent with these Terms of Use including any conditions relating to specific Services or websites outlined below.
          
          6.	If you do not comply with these Terms of Use, we may block your access to the Services or websites.
          
          Background
          
          1.	The information provided in Services and on the 20one websites is there to inform those making decisions about the funding of care and research and to assist health and social care practitioners and researchers and others to improve the quality of care, treatment and research. 
          
          2.	The websites are also accessible by the general public globally. Members of the general public may also find them of interest and may use them to inform discussions with practitioners or researchers and those who make decisions about the funding of care or research. 
          
          3.	Information retrieved from the websites do not override the individual responsibility of healthcare and social care professionals involved in the delivery of care to make informed professional judgments appropriate to the circumstances of the individual, in consultation with the individual and/or their guardian or carer. 
          
          4.	Practitioners, commissioners, researchers and managers are reminded of their duties to avoid unlawful discrimination and to have regard to promoting equality of opportunity. No material on the websites should be interpreted in a way which would be inconsistent with compliance with those duties. 
          
          5.	If you are an individual who chooses to access the information on the websites, you should not rely on that information as professional medical advice or use it to replace any relationship with your doctor or other qualified healthcare or social care professional. For medical concerns, including decisions about medications and other treatments, individuals should always consult their doctor or, in serious cases, seek immediate assistance from emergency personnel. Individuals with any type of medical condition are specifically cautioned to seek professional medical advice before beginning any sort of health treatment. If you are a member of the public, 20one recommends that you should evaluate the information on the websites together with your physician or another qualified healthcare or social care professional. 
          
          6.	In relation to the mention of any scientific evidence and the interpretation of it: It is in the nature of scientific debate that not all authors will agree on all matters. Further, published papers may be in error, or superseded by later research. It is the user's sole responsibility to assess all evidence and to reach a decision informed by it. 
          
          Definitions 
          
          Except to the extent expressly provided otherwise, in these Terms and Conditions: 
          
          "Charges" means the following amounts: 
          
          a.	The amounts specified in the Statement of Work; 
           
          b.	such amounts as may be agreed in writing by the parties from time to time; and 
          
          c.	amounts calculated by multiplying the Client Manager’s standard time-based charging rates by the time spent by the Client Manager’s personnel performing the Services (rounded by the Client Manager to the nearest plus or minus 5 minutes);
          
          "Client Materials" means all works and materials supplied by or on behalf of the Client to the Client Manager for incorporation into the Deliverables or for some other use in connection with the Services; 
           
          "Client Manager" means the authorized representative of 20one Consulting
           
          "Contract" means a particular contract made under these Terms and Conditions between the Client Manager and the Client; 
           
          "Deliverables" means those specified in the Statement of Work that the Client Manager has agreed to deliver to the Client under these Terms and Conditions; 
           
          "Effective Date" means the date of receipt of the signed version of this document by the Client Manager 
           
          "Intellectual Property Rights" means all intellectual property rights wherever in the world, whether registrable or unregistrable, registered or unregistered, including any application or right of application for such rights (and these "intellectual property rights" include copyright and related rights, database rights, confidential information, trade secrets, know-how, business names, trade names, trade marks, service marks, passing off rights, unfair competition rights, patents, petty patents, utility models, semi-conductor topography rights and rights in designs); 
           
          "Services" means the consultancy services specified in the Statement of Work; 
           
          "Statement of Work" means a written statement of work agreed by or on behalf of each of the parties, this may be referred to other names in practice such as “Projects”, “Scope” and “Deliverables”; new Statement of Works will be created ongoingly during your relationship with 20one Consulting in which case this same contract shall apply to all;
           
          "Term" means the term of the Contract 
           
          "Terms and Conditions" means all the documentation containing the provisions of the Contract, namely the main body of these Terms and Conditions and the Statement of Work, including any amendments to that documentation from time to time; and 
           
          "Third Party Materials" means the works and/or materials comprised in the Deliverables (excluding the Client Materials), the Intellectual Property Rights in which are owned by a third party and which may be specified in the Statement of Work or which the parties agree in writing shall be incorporated into the Deliverables. 
          
          Availability of the websites
          
          1.	We will make reasonable endeavours to ensure that these websites are generally available but make no representation or guarantees as to such availability.
          
          2.	We reserve the right to withdraw access to all or any part of any of these websites for periods of time in order to modify any of the content, for scheduled or unscheduled maintenance and for other purposes, without notice to you.
          
          3.	As you will receive these websites via third party telecommunications networks, you acknowledge that 20one cannot guarantee that the availability of these websites will be uninterrupted or error free. Similarly, we cannot guarantee that the transmission of any information over such telecommunications networks will be secure nor that you will be able to access these websites at all times.
          
          4.	These websites are therefore provided to you on an “as is” and “as and when available” basis, and your use of these websites is at your own risk.
          
          Disclaimers in terms of use of our websites
          
          1.	We have processes in place to seek to ensure that the contents of these websites are accurate and that the links it publishes directing the user to third party websites function properly. However, we give no assurances regarding the currency, accuracy or applicability of any of the website's content.
          
          2.	Due to the nature of these websites we cannot guarantee the prompt editing or removal of any inappropriate or inaccurate information. If you find any information that is inaccurate or inappropriate then please contact us.
          
          3.	While we use virus checkers to check the content of these websites we are unable to guarantee that these websites will never be faulty, nor that it will work continuously, nor that it will be maintained in a fully operational condition nor virus and/or error free. However, we will use reasonable endeavours to correct serious faults reported by you as soon as we reasonably can.
          
          4.	You should always check any content before downloading. Any website content is downloaded by you at your own risk and on the basis that you will be solely responsible for any damage to your computer system or loss of data that result from the download of such content.
          
          5.	Without prejudice to any other limitations or exclusions of our liability in these Terms of Use we shall have no liability whatsoever in respect of any failure on our part to repair a fault in these websites or to provide continuous access to it.
          
          6.	Without prejudice to any other limitations or exclusions of our liability in these Terms of Use we shall have no liability whatsoever in respect of any inability on your part to obtain access to these websites whether through any denial of service, attack or otherwise.
          
          7.	You are responsible for the provision of and payment for all telecommunications services necessary to use these websites and all hardware, equipment and other services (including but not limited to computers, modems and any other communication equipment) necessary to use these websites.
          
          8.	We provide these websites to you without any conditions, warranties, or guarantees whether express or implied, including but not limited to any implied warranties or conditions as to the satisfactory quality or fitness for a particular purpose, which are expressly excluded to the extent permitted by law.
          
          Disclaimer & Acknowledgements in respect of the use of 20one’s Services, Documents & Websites
          
          General
          
          1.	The use of 20one’s Services, Documents & Websites is subject to any disclaimer included within the guidance and the following disclaimer which applies to any recipient of 20one’s Services, Documents & Websites whether they be a clinical professional, researcher or member of the public.
           
          2.	This guidance represents the view of 20one, which was arrived at after careful consideration of the evidence available. Healthcare professionals are expected to take it fully into account when exercising their clinical judgement. However, the guidance does not override the individual responsibility of healthcare professionals to make decisions appropriate to the circumstances of the individual patient, in consultation with the patient and/or guardian or carer.
          
          3.	Implementation of guidance is the responsibility of local commissioners and/or providers. Commissioners and providers are reminded that it is their responsibility to implement the guidance, in their local context, in light of their duties to avoid unlawful discrimination and to have regard to promoting equality of opportunity. Nothing in this guidance should be interpreted in a way which would be inconsistent with compliance with those duties.
          
          Nature of information
          
          1.	Our Services and websites do not provide medical advice.
           
          2.	The contents of our Services are scientific information only and is not intended to diagnose, treat, cure or prevent any disease, disorder, injury or to act as triage.
          
          3.	The contents of our Services and websites, such as text, graphics, images, information obtained from our licensors, and other material contained are for informational, educational and research purposes only
          
          4.	Our staff cannot provide medical advice, and may not be registered, licensed or insured to practice medicine in any certain jurisdiction. 
          
          5.	If staff whom hold primary medical qualifications (medical degrees) or other statutory healthcare professionals have contributed to the development of any work they are NOT acting in their capacity as any of the listed statutory healthcare professionals in the UK or as relevant to their international jurisdiction, only in their capacity as non-statutory scientific researchers. 
          
          6.	You must not rely on the information supplied from our Services or websites as an alternative to medical advice from your doctor or other professional healthcare provider.   
          
          7.	If you have any specific questions about any medical matter you should consult your doctor or other professional healthcare provider.
          
          8.	If you think you may be suffering from any medical condition you should seek immediate medical attention.  
          
          9.	You should never delay seeking medical advice, disregard medical advice, or discontinue medical treatment because of information included in our Services or websites
          
          10.	Reliance on any information from our Services or websites is at your own risk. 20one is not responsible or liable for any advice, course of treatment, diagnosis, drug and device application or other information, services, or products that you obtain as a result of Services or websites we provide.
          
          11.	I am aware that I am strongly encouraged to discuss any documents generated by the Services or websites with my licensed doctor. We recommend that you always consult an appropriate healthcare professional for advice on your specific circumstances and situation
          
          12.	You acknowledge and agree that the Services are not a substitute for actual medical diagnosis, treatment or consultation with a doctor, and that any of 20one’s information does not constitute medical advice and/or recommendations for medical treatment regarding any aspect of your health, medicine intake, nutrition or lifestyle. 
          
          3rd parties
           
          1.	Mention of specific companies, organisations or authorities within any of 20one Consulting’s products and services does not imply endorsement by 20one Consulting’s staff, advisors or associates, nor does mention of specific companies, organisations or authorities imply that they endorse any of the 20one Consulting products and services, or 20one Consulting’s staff, advisors or associates. 
          
          Information provided
          
          1.	20one Consulting and Staff have made reasonable effort to ensure the accuracy of data or information used in 20one Consulting Deliverables. However, 20one Consulting Staff, Advisors and Associates cannot accept responsibility for any errors or omission, or for any consequences from application of the data or information provided through 20one Consulting Deliverables, and make no warranty, expressed or implied, with respect to the currency, completeness or accuracy of the data and information within 20one Consulting Deliverables.
          
          2.	No guarantee can be made whether developed Deliverables will meet your expectations for Deliverables recommendations or content, or that you will be able to implement these Deliverables as an organisation, a clinician or as an individual wanting a clinician to use such Deliverables.
          
          Data security
          
          1.	Whilst 20one Consulting has gone to reasonable efforts to secure all client data through utilising security protocols, 20one Consulting holds no responsibility for the undesired breach, damage or loss of any such client data.   
          
          Personal injury 
          
          1.	20one Consulting holds no responsibility for any injury, damage or undesired alteration to the client’s body acquired during use of our service.
          
          Links
          
          1.	The Services and websites contain links to websites which are not under our control. These links are provided for your convenience only. We are not responsible for the availability or content of such other websites, nor for any products or services available from them. Any such link should not be seen as an endorsement by us of such websites, or any of the products or services contained on them. Links are made to or from the website at your own risk.
          
          2.	You should be aware that your use of such other websites may be subject to additional terms and conditions imposed by the owners of those websites. Your dealings with such third parties are between you and the third party, and we accept no liability as a result of you accessing such websites or entering into contractual arrangements with the operator in question.
          
          3.	Users may insert a simple link to the 20one websites from their own website provided that: 
          
          a.	the website on which the link appears contains no unlawful, obscene, or offensive content and does not contain any links to such content;
          
          b.	the website on which the link appears is not likely to cause anxiety, loss, harm or personal injury to its readers; and
          
          c.	the link in no way has a negative impact on the reputation of 20one.
          
          4.	We reserve the right to terminate any links to the website at any time without notice and at our sole and absolute discretion.
          
          Limitations and exclusions of liability 
          
          1.	Nothing in these Terms and Conditions will: 
           
          a.	limit or exclude any liability for death or personal injury resulting from negligence; 
           
          b.	limit or exclude any liability for fraud or fraudulent misrepresentation; 
           
          c.	limit any liabilities in any way that is not permitted under applicable law; or 
           
          d.	exclude any liabilities that may not be excluded under applicable law. 
           
          2.	The limitations and exclusions of liability set out in this document:
            
          a.	govern all liabilities arising under these Terms and Conditions or relating to the subject matter of these Terms and Conditions, including liabilities arising in contract, in tort (including negligence) and for breach of statutory duty, except to the extent expressly provided otherwise in these Terms and Conditions. 
           
          3.	Neither party shall be liable to the other party in respect of any loss of profits or anticipated savings. 
           
          4.	Neither party shall be liable to the other party in respect of any loss of revenue or income. 
           
          5.	Neither party shall be liable to the other party in respect of any loss of use or production. 
           
          6.	Neither party shall be liable to the other party in respect of any loss of business, contracts or opportunities. 
           
          7.	Neither party shall be liable to the other party in respect of any loss or corruption of any data, database or software. 
           
          8.	Neither party shall be liable to the other party in respect of any special, indirect or consequential loss or damage. 
          
          Jurisdiction
          
          1.	These Terms and Conditions shall be governed by and construed in accordance with English law. 
           
          2.	The courts of London or Cambridge, England shall have exclusive jurisdiction to adjudicate any dispute arising under or in connection with the Contract. 
          
          Amending these terms of use in respect to our websites only
          
          1.	From time to time 20one may at its sole discretion amend these Terms of Use relevant to our websites only. Your continuing use of these websites constitutes your acceptance of and agreement to any changed terms and conditions. 20one will post details of any such changes on the websites in a timely manner.
          
          Amending these terms of use in respect of consultancy Services
          
          1.	The Contract may not be varied except by a written document signed by or on behalf of each of the parties
          
          General (Breaches, Unenforceability, Contractual Rights Deals, Superseding)
          
          1.	No breach of any provision of the Contract shall be waived except with the express written consent of the party not in breach. 
           
          2.	If any provision of the Contract is determined by any court or other competent authority to be unlawful and/or unenforceable, the other provisions of the Contract will continue in effect. If any unlawful and/or unenforceable provision would be lawful or enforceable if part of it were deleted, that part will be deemed to be deleted, and the rest of the provision will continue in effect (unless that would contradict the clear intention of the parties, in which case the entirety of the relevant provision will be deemed to be deleted).  
           
          3.	The Contract is made for the benefit of the parties, and is not intended to benefit any third party or be enforceable by any third party. The rights of the parties to terminate, rescind, or agree any amendment, waiver, variation or settlement under or relating to the Contract are not subject to the consent of any third party.
          
          4.	Neither party may without the prior written consent of the other party assign, transfer, charge, license or otherwise deal in or dispose of any contractual rights or obligations under these Terms and Conditions. 
          
          5.	Subject to the relevant Clauses in this document, a Statement of Work, together with these Terms and Conditions, shall constitute the entire agreement between the parties in relation to the subject matter of that Statement of Work, and shall supersede all previous agreements, arrangements and understandings between the parties in respect of that subject matter.
          
          Term 
          
          4.	The Contract shall come into force upon the Effective Date. 
           
          5.	The Contract shall continue in force until the Client expresses in writing their desire for the termination of the contract 
          
          Services & Quality Assurance
          
          1.	The Client Manager shall provide the Services to the Client in accordance with these Terms and Conditions. 
           
          2.	The Client Manager shall provide the Services with in accordance with the standards of skill and care reasonably expected from a leading service provider in the Client Manager’s industry 
           
          Deliverables 
          
          1.	The Client Manager shall deliver the Deliverables to the Client. 
          
          2.	The Client Manager shall use reasonable endeavours to ensure that the Deliverables are delivered to the Client in accordance with the timetable set out in the Statement of Work. 
           
          3.	The Client Manager warrants to the Client that: 
           
          a.	the Deliverables will conform with the requirements of the Statement of Work; 
           
          b.	the Deliverables will be free from material defects; and 
           
          c.	the use of the Deliverables by the Client in accordance with these Terms and Conditions will not: 
           
          1.	breach the provisions of any law, statute or regulation; 
          2.	infringe any third party's Intellectual Property Rights; or 
          3.	give rise to any cause of action against the Client, 
          
          in each case in any jurisdiction and under any applicable law. 
          Charges 
          
          1.	The Client and the Client Manager shall agree the Charges prior to undertaking of any work 
          
          2.	The Client Manager may increase charges on a roughly annual basis to reflect changes in demand to the service or increases in quality or efficiency, in which case this will be discussed with the Client in advance
          
          3.	The Client shall pay the Charges to the Client Manager in accordance with these Terms and Conditions. 
          
          4.	The Charges rate shall be agreed separately to this document on a staff by staff basis and reviewed from time to time.
           
          5.	All amounts stated in or in relation to these Terms and Conditions are, unless the context requires otherwise, stated exclusive of any applicable value added taxes, which will be added to those amounts and payable by the Client to the Client Manager. 
          
          6.	Value added tax (VAT) shall be added to the fees and expenses as and to the extent required by law. 
          
          7.	In case VAT is not initially charged, the Client Manager has the right to charge such VAT later should it be determined by the relevant tax authorities that VAT should be charged. 
           
          Payments 
          
          1.	The Client Manager shall issue invoices for the Charges to the Client from time to time during the Term 
           
          2.	The Client must pay the Charges to the Client Manager within the period of 30 days following the receipt of an invoice issued
          
          3.	The Client must pay the Charges by debit card, credit card, direct debit, or bank transfer, using such payment details as are notified by the Client Manager to the Client from time to time.
           
          4.	If the Client does not pay any amount properly due to the Client Manager under these Terms and Conditions, the Client Manager may: 
          
          a.	charge the Client interest on the overdue amount at the rate of 8% per annum above the Bank of England base rate from time to time (which interest will accrue daily until the date of actual payment and be compounded at the end of each calendar month); or 
           
          b.	claim interest and statutory compensation from the Client pursuant to the Late Payment of Commercial Debts (Interest) Act 1998. 
          
          Warranties: Quality & Legality of Service
          
          1.	The Client Manager warrants to the Client that: 
          
          a.	the Client Manager has the legal right and authority to enter into the Contract and to perform its obligations under these Terms and Conditions;
          
          b.	the Client Manager will comply with all applicable legal and regulatory requirements applying to the exercise of the Client Manager’s rights and the fulfilment of the Client Manager‘s obligations under these Terms and Conditions; and
          
          c.	the Client Manager has or has access to all necessary know-how, expertise and experience to perform its obligations under these Terms and Conditions. 
           
          2.	The Client warrants to the Client Manager that it has the legal right and authority to enter into the Contract and to perform its obligations under these Terms and Conditions.
          
          3.	All of the parties' warranties and representations in respect of the subject matter of the Contract are expressly set out in these Terms and Conditions and the applicable Statement of Work. Subject to the relevant Clauses in this document, no other warranties or representations will be implied into the Contract and no other warranties or representations relating to the subject matter of the Contract will be implied into any other contract.
           
          Termination 
          
          1.	Either party may terminate the Contract by giving to the other party at least 30 days written notice of termination. 
           
          2.	Either party may terminate the Contract immediately by giving written notice of termination to the other party if the other party commits a material breach of these Terms and Conditions. 
           
          3.	Either party may terminate the Contract immediately by giving written notice of termination to the other party if: 
           
          a.	the other party: 
           
          1.	is dissolved; 
          2.	ceases to conduct all (or substantially all) of its business; 
          3.	is or becomes unable to pay its debts as they fall due; 
          4.	is or becomes insolvent or is declared insolvent; or 
          5.	convenes a meeting or makes or proposes to make any arrangement or composition with its creditors; 
           
          b.	an administrator, administrative receiver, liquidator, receiver, trustee, manager or similar is appointed over any of the assets of the other party; 
           
          c.	an order is made for the winding up of the other party, or the other party passes a resolution for its winding up (other than for the purpose of a solvent company reorganisation where the resulting entity will assume all the obligations of the other party under the Contract); or 
           
          d.	if that other party is an individual: 
          
          1.	that other party dies; 
          2.	as a result of illness or incapacity, that other party becomes incapable of managing his or her own affairs; or 
          3.	that other party is the subject of a bankruptcy petition or order. 
           
          Effects of termination 
          
          1.	Upon the termination of the Contract, all of the provisions of these Terms and Conditions shall cease to have effect, save that the following provisions of these Terms and Conditions shall survive and continue to have effect (in accordance with their express terms or otherwise indefinitely): [Clauses X]
           
          2.	The termination of the Contract shall not affect the accrued rights of either party. 
           
          Status of Client Manager 
          
          1.	The Client Manager is not an employee of the Client, but an independent contractor. 
          
          2.	The Client Manager is not acting in the role of a statutory healthcare professional, there is no doctor-patient relationship and no medical advice, including triage, diagnosis, preventive or reactive treatment can be provided. Do not make any changes to your health behaviours based on any of 20one’s Services, documents or websites without consulting your licensed healthcare professionals first.
           
          3.	The termination of the Contract will not constitute unfair dismissal; nor will the Client Manager be entitled to any compensation payments, redundancy payments or similar payments upon the termination of the Contract. 
          
          Subcontracting 
          
          1.	The Client Manager may subcontract any of its obligations under the Contract providing that the Consultant must give to the Client, promptly following the appointment of a subcontractor, a written notice specifying the subcontracted obligations and identifying the subcontractor in question. 
           
          2.	The Client Manager shall remain responsible to the Client for the performance of any subcontracted obligations.  
          
          Intellectual property rights
          
          1.	You acknowledge that all rights in copyright, patents, design rights, trade marks and other intellectual property rights (whether registered, capable of registration or otherwise) throughout the world, ("IP Rights") in the websites (including in all content) are owned by 20one and/or our licensors or other third parties, for the full duration of such rights.
          
          2.	Except for your use of the websites in accordance with these Terms of Use, you are granted no IP Rights in respect of the Services or websites or their content.
          
          3.	All trade marks, logos, titles, brand and product names ("the Trade Marks") which are featured on the website are owned by 20one, or our licensors.
          
          4.	You may only use or refer to the Trade Marks which are included in those extracts from the Services or website downloaded, copied or printed by you in accordance with these Terms of Use. Otherwise you must not offer or distribute any products or services under or by reference to the Trade Marks, or otherwise reproduce any of the Trade Marks without our express written consent
          
          5.	Reproduction, publication or distribution of the content from the website, including 20one copyright material, is subject to the following 'Notice of Rights'.
          
          Notice of rights
          
          Use of 20one content
          
          6.	Except for personal use, study or personal research, copyright content owned by 20one may not be used, reproduced, translated, distributed or transmitted in any form, in whole or in part, by any means, electronic, mechanical, photocopying, recording or other means, now known or hereafter invented, or used in any information or retrieval system, without the prior written agreement of 20one. Such an agreement may be subject to a licence and fee. 
          
          Third-party content included in 20one content
          
          7.	Some 20one content includes identifiable third-party content for which 20one will have sought permission for its inclusion. It is therefore for you to seek the necessary additional permission to re-use any content in the 20one content which is identifiable as being sourced from, or owned by, a third party. This may include, but is not limited to: text extracts, third-party review and comment, official publications, data, tables, illustrations and/or photography. This also includes content that 20one has acknowledged it has adapted. 20one makes no warranty in relation to any material identified as sourced from third parties in the 20one content.
          
          Third-party content hosted on the 20one website
          
          8.	The 20one website hosts identifiable third-party content under licensing agreements with the specific content providers. You may print copy or download the content from the website for educational and not-for-profit purposes only. It is therefore for you to seek permission directly from the content provider to re-use any hosted content which is identifiable as being owned by a third party.
          
          Products for Personal Use Only
          The products available on the Site, and any samples thereof we may provide to you, are for personal use only. You may not sell or resell any of the products or samples thereof that you purchase or otherwise receive from us. We reserve the right, with or without notice, to cancel or reduce the quantity of any order to be filled or products to be provided to you that we believe, in our sole discretion, may result in the violation of these Terms.
          Payment and Order Terms
          The Services enable you to order products from 20one Consulting. The amounts due and payable by you for any product that you purchase through the Services (including applicable taxes, shipping and handling) will be presented to you before you place your order. If you place an order for any products via the Services, you agree (a) that 20one Consulting may charge your credit card for verification, pre-authorization and payment purposes, and (b) to bear any additional charges that your bank or other financial service provider may levy on you as well as any taxes or fees that may apply to your order. Your order is not binding on 20one Consulting until accepted and confirmed by 20one Consulting.
          Subscriptions Automatically Renew Until you Cancel & How to Cancel Your Subscription
          All amounts are payable and charged: (i) for one-off purchases, at the time you place your order; and (ii) FOR SUBSCRIPTION-BASED PURCHASES, AT THE BEGINNING OF THE SUBSCRIPTION AND, BECAUSE EACH SUBSCRIPTION RENEWS AUTOMATICALLY UNTIL YOU CANCEL IT, AT THE TIME OF EACH RENEWAL UNTIL YOU CANCEL. You must cancel your subscription before it renews to avoid the billing of the fees for the next subscription period. YOU CAN CANCEL THE RENEWAL OF YOUR SUBSCRIPTION AT ANY TIME by contacting us by email at oliver@20one.consulting. You will not receive a refund for the fees you already paid for your current subscription period and you will continue to receive products ordered until the end of your current subscription period.
          When ordering, it is your responsibility to ensure that all information submitted to 20one Consulting is accurate. You may not be able to submit corrections after you place an order, and, if accepted, any corrections submitted after you place an order may significantly delay shipping of your order.
          Unless expressly specified payments made to us are non refundable.
          We reserve the right to limit the order quantity on any product, to extend the delivery timeline for any reason after the order has been placed and accepted, and/or refuse to ship product to you for any reason. If you have any concerns or objections regarding charges, you agree to raise them with us first and you agree not to cancel or reject any credit card charges unless you have made a reasonable attempt at resolving the matter directly with 20one Consulting.
          20one Consulting reserves the right to not process or to cancel your order in certain circumstances, for example, if your credit card is declined, if we suspect the request or order is fraudulent, or in other circumstances 20one Consulting deems appropriate in its sole discretion. 20one Consulting also reserves the right, in its sole discretion, to take steps to verify your identity in connection with your order. 20one Consulting will either not charge you or refund the charges for orders that we do not process or cancel.
          Risk of Loss, Return Policies, and FAQ
          Title to products passes from 20one Consulting to you upon shipment from 20one Consulting’s facility. For information on order processing and shipping, please see our Shipping FAQ. Please be aware that our shipping times are only estimates and are subject to change.
          If you desire to return any product you ordered through the Services, please refer to our Return Policy FAQ for how you may return the product.
          
          General Prohibitions and 20one Consulting’s Enforcement Rights
          You agree not to do any of the following:
          • Use the Services in any way, or upload, publish, submit or transmit any Content that: (i) infringes, misappropriates or violates a third party’s patent, copyright, trademark, trade secret, moral rights or other intellectual property rights, or rights of publicity or privacy; (ii) violates, or encourages any conduct that would violate, any applicable law or regulation or would give rise to civil liability; (iii) is fraudulent, false, misleading or deceptive; (iv) is defamatory, obscene, pornographic, vulgar or offensive; (v) promotes discrimination, bigotry, racism, hatred, harassment or harm against any individual or group; (vi) is violent or threatening or promotes violence or actions that are threatening to any person or entity; or (vii) promotes illegal or harmful activities or substances.
          • Use, display, mirror or frame the Services, or any individual element within the Services, 20one Consulting’s name, any 20one Consulting trademark, logo or other proprietary information, or the layout and design of any page or form contained on a page, without 20one Consulting’s express written consent;
          • Access, tamper with, or use non-public areas of the Services, Client’s computer systems, or the technical delivery systems of Client’s providers;
          • Attempt to probe, scan, or test the vulnerability of any 20one Consulting system or network or breach any security or authentication measures;
          • Avoid, bypass, remove, deactivate, impair, descramble or otherwise circumvent any technological measure implemented by 20one Consulting or any of 20one Consulting’s providers or any other third party (including another user) to protect the Services or Content;
          • Attempt to access or search the Services or Content or download Content from the Services through the use of any engine, software, tool, agent, device or mechanism (including spiders, robots, crawlers, data mining tools or the like) other than the software and/or search agents provided by 20one Consulting or other generally available third party web browsers;
          • Use any meta tags or other hidden text or metadata utilizing a 20one Consulting trademark, logo, URL or product name without 20one Consulting’s express written consent;
          • Use the Services or Content for any commercial purpose or for the benefit of any third party or in any manner not permitted by these Terms;
          • Attempt to decipher, decompile, disassemble or reverse engineer any of the software used to provide the Services or Content;
          • Interfere with, or attempt to interfere with, the access of any user, host or network, including, without limitation, sending a virus, overloading, flooding, spamming, or mail-bombing the Services;
          • Collect or store any personally identifiable information from the Services from other users of the Services without their express permission;
          • Impersonate or misrepresent your affiliation with any person or entity;
          • Violate any applicable law or regulation; or
          • Encourage or enable any other individual to do any of the foregoing.
          Although we’re not obligated to monitor access to or use of the Services or Content or to review or edit any Content, we have the right to do so for the purpose of operating the Services, to ensure compliance with these Terms, or to comply with applicable law or other legal requirements. We reserve the right, but are not obligated, to remove or disable access to any Content, at any time and without notice, including, but not limited to, if we, at our sole discretion, consider any Content to be objectionable or in violation of these Terms. We have the right to investigate violations of these Terms or conduct that affects the Services. We may also consult and cooperate with law enforcement authorities to prosecute users who violate the law.
          Links to Third Party Websites or Resources
          The Services may contain links to third-party websites or resources. We provide these links only as a convenience and are not responsible for the content, products or services on or available from those websites or resources or links displayed on such sites. You acknowledge sole responsibility for, and assume all risk arising from, your use of any third-party websites or resources.
          
          20one Consulting Products
          20one Consulting EXPRESSLY DISCLAIMS ALL LIABILITY FOR CLAIMS THAT ARE DUE TO NORMAL WEAR, PRODUCT MISUSE, ABUSE, PRODUCT MODIFICATION, IMPROPER PRODUCT SELECTION AND NON-COMPLIANCE WITH ANY PRINTED DIRECTIONS.
          TO THE EXTENT NOT PROHIBITED BY LAW, IN NO EVENT WILL 20ONE CONSULTING BE LIABLE FOR ANY SPECIAL, INDIRECT, CONSEQUENTIAL, INCIDENTAL OR PUNITIVE DAMAGES, HOWEVER CAUSED AND REGARDLESS OF THE THEORY OF LIABILITY, ARISING OUT OF OR RELATED TO 20ONE CONSULTING’S PRODUCTS, EVEN IF 20ONE CONSULTING HAS BEEN ADVISED OF THE POSSIBILITY OF SUCH DAMAGES. IN NO EVENT WILL 20ONE CONSULTING’S LIABILITY EXCEED THE AMOUNT PAID BY YOU FOR THE PRODUCT UPON WHICH A CLAIM IS BASED. SOME JURISDICTIONS DO NOT ALLOW THE EXCLUSION OR LIMITATION OF LIABILITY FOR CONSEQUENTIAL OR INCIDENTAL DAMAGES, SO THE ABOVE LIMITATION MAY NOT APPLY TO YOU.
          
          
          
          
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