• WineSpan. For Lifespan.

    Alcohol Free.

    WineSpan is the only red wine supplement that has the exact same polyphenol profile as red wine. Allowing you to gain the benefits of wine without the alcohol.

     

    Developed by Oliver Zolman MD, only WineSpan polyphenols have been:

    • Associated with +5 years increased lifespan in men, +2 in women 
    • Proven to raise 3 antioxidant enzymes by 10%, 50% and 150% 
    • Proven to reduce the rise in oxidised LDL  100% after a meal
    • Proven to reduce the rise in cytotoxic MDA by 100% after a meal
    • In men at high heart disease risk: lowered blood pressure by 6 points
    Each 60 pill pack is designed to be equivalent to a large glass of French red wine per day, the same as 12 bottles of red wine per month, or 150 bottles per year. Saving over 4000 calories intake per month.
     
    Who is WineSpan for?
    People who do not want or cannot consume alcoholic or dealcoholised wine everyday, or as an add on supplement in people that consume alcoholic wine to enhance its benefits.
     
     
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  • 500 different molecules

    One unique composition.

    WineSpan is the only molecularly identical red wine extract. Created through gentle evaporation of the ethanol from real French red wine, WineSpan leaves the unique molecular composition of red wine intact.

     

    The benefits of alcoholic red wine are thought to be majorly due to its polyphenol content, and not ethanol. This is because the same amount of ethanol from beer, spirits or white wine is not associated with the same lifespan benefit or randomised controlled trial evidence.

  • Tested and proven

    WineSpan is the only supplement that maintains the exact polyphenol composition of real French red wine.

    Dealcoholised red wine is backed by 3 human randomised controlled clinical trials (RCTs)

    Wine is associated in 3 Lifespan studies with 2-5 years increased lifespan, even in already very healthy people

    Increased 3 antioxidant defence systems by 10%, 50% and 150% in 7 days in those on a normal polyphenol diet. (RCT)

    Reduced the rise in toxic MDA by 100% if added to food before high temperature cooking (RCT)

    Reduced the rise in oxidised LDL cholesterol by 100% in diverse adult populations. White wine had no effect. (2 RCTs)

    Lowers blood pressure by 6 points and boosts nitric oxide in men age 55+ with 3 or more cardiovascular risk factors (RCT)

  • Developed by Oliver Zolman MD

    "I made WineSpan due to its potential benefits and it seemingly having no risks other than financial opportunity cost and sulphite allergies or intolerances. WineSpan can be used either as an addition to a glass of wine, or to allow alcohol abstainers to potentially gain the benefits of low dose wine consumption. Both myself and my parents take WineSpan as part of our longevity supplement protocol."

     

    Pricing of WineSpan?

    WineSpan is ethically priced with a low profit margin, and unless you are buying the cheapest wine possible, it is cheaper than buying wine in the UK.

     

    Given every pack of WineSpan is made from real French red wine, with the ethanol removed, and equivalent to 12.8 bottles of wine per pack, unfortunately it is not a cheap ~£5 a month supplement like many others. The price is currently £50 / $68 per bottle, equivalent to buying a bottle of French red wine for £3.90 (£4) or $5 USD or 4.5 EUR.

     

    The low profit margin pricing of WineSpan allows people of lower income families to access WineSpan. A common problem in the longevity supplement industry is the huge price hiking, where companies mark up the cost of ingredients to a 500% - 1000% profit margin and are deliberately mislead customers into thinking they cannot get the same product anywhere else, cheaper.

     

    Alternatives to WineSpan?

     

    Option 1: Non-alcoholic wine: WineSpan is available no where else, however you can buy dealcohlised bottles of red wine for a similar price to WineSpan in most UK or US supermarkets. The common disadvantage of these is that they are sweetened, so may boost blood sugar levels and have an odd taste from personal experience. These calories are "junk" sugar calories too as they are not from ethanol and is not ideal for a calorie restriction optimal nutrition diet (CRON).

     

    Option 2: Non-molecularly identical red wine polyphenols: There are many "red wine polyphenols" or "grape skin polyphenols" supplements on the market, however none of these contain the same polyphenols as fermented french red wine, the polyphenol molecules change a lot during the wine fermentation process and there is no evidence that these compounds have the same benefits as red wine polyphenols. This is not to say grape seed derived polyphenols have no benefit: for example a RCT showed that 200 mg a day of oligomeric proanthocyanidins (these are a subclass of flavonoids which are a subclass of polyphenols) from grape seed extract reversed atherosclerosis (plaques in the neck carotid artery on ultrasound scan) by 6% after 2 years in a broad population of BMI 24 men.

     

    Option 3: Doing nothing (taking no wine related supplements): You can still gain lifespan benefits from other longevity level 1 components, such as diet, exercise, BMI control, calorie restriction optimal nutrition and smoking cessation or alcohol reduction & drinking alcoholic red wine; however the wine's lifespan benefit might stack on top of all of these.

     

    Option 4: Drinking red wine: Drinking red wine will provide at least the same benefits of WineSpan (and maybe more for some people due to the potential theoretical (but unproven) benefits of ethanol itself), but comes with the following downsides in some people

    1. 4000 calories per month extra (1 medium 175 mL glass of red wine per day is 140 calories. 140 x 30 days a month = 4200 calories)
    2. Cognitive changes that are unwanted in some people 
    3. Religious incompatibility in some religions 
    4. Requirement to store 8 bottles of wine per month, taking up space
    5. Not compatible with certain medications
    6. Can be more expensive (if not buying the cheapest wine)
    7. Requires accurate dosing of wine to not have too much
    8. Non-sulphite wine component intolerances, such as tannins, causing headaches etc (note WineSpan contains Sulphites as it is hard to extract these without affecting the polyphenol composition)
    9. Active liver or kidney disease may contraindicate alcohol
    10. Hard to get around it 'tasting bad' for some people
    11. Requires enhanced dental cleaning in some people to stop stains
    12. Even a small or medium glass of red wine may disrupt sleep in some people even when taken with dinner, due to ethanol content
    13. Some have ethanol dehydrogenase enzyme genetic variants that mean they metabolise ethanol very slowly and cannot even drink small amounts, even after repeat exposure
    14. In people with alcohol excessive use disorders or predispositions, even a small glass of red wine per day can be contraindicated  
    Option 5: Winespan
    WineSpan is based on the 10 studies below on this page.
     
    The product is designed for each serving to
     
    1) exceed an above average polyphenol content glass of large red wine (>450 mg) and
     
    2) reliably match or exceed all doses of red wine polyphenols used in red wine polyphenol randomised controlled trials (RCTs) (>540 mg).
     
    The average polyphenol content of red wine is 1800 mg/L as shown in Pubmed Reference.

  • The 10 studies that inspired me to create WineSpan

    Lifespan study #1

    Life expectancy was 5 years longer in men who consumed 0.5-1.5 units wine a day, but not beer or spirits

     

    Even after adjusting for 18 confounding factors. (Link to study)

     

    Population: 1373 Dutch men followed for 40 years.

     

    Intervention: 0.5-1.5 units wine per day

     

    Control group: No alcohol, or beer or spirits or more than 2 units wine per day

     

    Confounders adjusted for: Former drinking, energy intake without alcohol, the number of cigarettes smoked, cigarette smoking duration, cigar or pipe smoking, intake of vegetables, fruit, fish, saturated and trans fatty acids, body mass index, prevalence of myocardial infarction, stroke, diabetes mellitus and cancer, baseline socioeconomic status and total alcohol intake

     

    Critique: Part of the effect size may be due to the control group including former drinkers, however the intervention group was adjusted for former drinking status.

     

    Author's quote: "For long-term wine consumers, consuming on average less than half a glass of wine per day, life expectancy at age 50 was about 5 years longer compared with no alcohol users"

     

    Relevance to WineSpan: Here we can see the benefit of alcohol drinking is likely not just due to ethanol, the alcohol molecule. Rather it is the unique polyphenol profile of wine that may provides benefits, and only WineSpan has the some molecular profile as real wine.

    Lifespan study #2

    Low dose alcohol intake is associated with +2 years lifespan in men and women, even in the top 5% healthiest people

     

    A 34 year long, 14 confounder adjusted observational study, adjusted for extensive dietary, BMI, exercise and smoking factors (Link)

     

    Population: 133,000 USA men and women from the NHANES cohort, were followed for 34 years from age 47 on average. They were mostly caucasian healthcare professionals.

     

    Observations: Every 2 - 4 years, for 34 years (12 readings per person for each variable on average) alcohol intake, BMI, weekly exercise hours, healthy diet score and smoking status were tracked.

     

    Outcomes: Even in people who exercised 6+ hours a week, who had the top 20% healthiest diet, were never smokers and who had optimal BMI, 0.5-1.5 units a day alcohol consumption taken for 34 years from age 50 onwards was associated with 2 years increased lifespan in men and women. Over 10 million Americans were followed for 34 years on average in this study.

     

    For the healthiest men that have a BMI 18.5-22.5, exercise 6+ hours a week, don't smoke and have a top 20% healthy diet, 0.5-1.5 units a day alcohol consumption may add another 6 years to average lifespan, giving 8 years total.

     

    Confounder Adjustments: The results were adjusted for 14 things to check that these were not responsible for the benefits of the specific lifestyle behaviours: alcohol intake, exercise, BMI, smoking status, weekly exercise hours, age; sex; ethnicity; current multivitamin use; current aspirin use; family history of diabetes mellitus, myocardial infarction, or cancer; and menopausal status and hormone use (women only).

     

    Relevance to WineSpan: Here we can see good epidemiological evidence that low dose alcohol intake of up to 1.5 units a day is healthier than zero intake. Whilst this does not provide specific evidence for WineSpan (whereas the other 7 studies in this analysis do) it is an important study to include to strengthen the case for the benefits of low dose alcohol and polyphenol consumption.

    Lifespan study #3

    Wine, not beer or spirits, may reduce risk of death from all causes the most. (Link to Meta Analysis of Observational Studies)

    Population: 6 observational studies of 57,000 people, and over 10,000 deaths, followed on average for 25 years.

     

    Intervention: 100 mL of wine per day

     

    Control group: No wine consumption, any beer or spirits consumption or over 400 mL wine consumption per day.

     

    Outcomes: 95% chance of at least a 14% reduction in death from any cause, 50% chance of a 25% reduction, and 5% chance of a 34% reduction versus no wine consumption or more wine consumption.

     

    Confounder adjusted for: Age, smoking, BMI (study 19), sex, age, expected level of need, total alcohol consumption (study 22), Consumption of other beverage types, smoking, BMI, physical activity, cohabitation, income and education (study 26), age (study 31), Former drinking, energy intake without alcohol, number of cigarettes smoked, cigarette smoking duration, cigar or pipe smoking, intake of vegetables, fruit, fish, saturated and trans fatty acids, body mass index, prevalence of AMI, stroke, diabetes mellitus and cancer, baseline socioeconomic status and total alcohol intake (study 32)

     

    Relevance to WineSpan: Here we can see the benefit of alcohol drinking is likely not just due to ethanol, the alcohol molecule. Rather it is the unique polyphenol profile of wine that may provides benefits, and only WineSpan has the some molecular profile as real wine.

    Lifespan study #4

    For women drinking low dose wine, but not spirits or beer, they were 21% - 68% more likely to reach age 90, even after adjusting for 16 potential confounding factors (Link to observational study)

     

    Relevance to WineSpan: Here we can see the benefit of alcohol drinking is likely not just due to ethanol, the alcohol molecule. Rather it is the unique polyphenol profile of wine that may provides benefits, and only WineSpan has the some molecular profile as real wine.

    Clinical trial #1: Dealcoholised red wine

    Increases 3 antioxidant defence systems by 10%, 50% and 150%

    A randomised controlled trial (Link)

    Population: Healthy people age 28 on average (25 - 40) who had eaten a low polyphenol diet for 2 days prior to starting the intervention, and stopped any vitamin, mineral, drug or antibiotics for 4 weeks before.

     

    Intervention: Drinking 300 mL dealcoholised red wine at dinner each day. This is equivalent to 540 mg* red wine polyphenols (as there are around 180 mg of polyphenols in 100 mL of commercial red wine (Reference)).

     

    *Each WineSpan capsule contains 320mg French red wine polyphenols. The recommended serving size is 1 - 2 capsules WineSpan per day, bringing the daily intake to around 640 mg polyphenols - that's 100 mg more than was used in this study.

     

    Control group: Each person was randomised to drink dealcoholised red wine for 1 week or follow a low polyphenol diet for 1 week and then crossed over to the other intervention to act as their own control group.


    Outcomes: Adjusted for 2 day washout period of low polyphenol diet:

    • Glutathione reductase activity increased from 44.5 to 50 U/L a 12% increase
    • Catalase activity increased from 10.7 to 16 nM/min/ml, a 50% increase
    • SOD (superoxide dismutase) activity increased from 58 to 182 U/mL of RBC, a 150% increase
    Relevance to WineSpan: Here we can see it is not the alcohol component of red wine that is providing the benefits, additionally this trial of dealcoholised red wine will have used near identical polyphenol content to WineSpan - taking into account the minor variation in polyphenol profile between red wines.

    Clinical trial #2: Dealcoholised red wine

    Lowers systolic and diastolic blood pressure by 6 and 2 points and increases nitric oxide by 4 uM in people at high cardiovascular risk (Link to RCT)

     

    Population: Sixty-seven 55-75 year old men, who had type 2 diabetes or 3 or more cardiovascular risk factors.

     

    Intervention: 300 mL dealcoholised red wine per day, equivalent to less than 1 serving of WineSpan.

     

    Control group: Alcoholic red wine or gin were given to the control groups.

     

    Outcomes: Only dealcoholised red wine:

    • Lowered systolic blood pressure by 6 points 
    • Lowered diastolic blood pressure by 2 points
    • Increased nitric oxide by 4 umol/L
      Relevance to WineSpan: Here we can see it is not the alcohol component of red wine that is providing the benefits, additionally this trial of dealcoholised red wine will have used near identical polyphenol content to WineSpan - taking into account the minor variation in polyphenol profile between red wines.

      Clinical Trial #3: Red Wine powder plus alcoholic red wine

      Prevented 100% of the absorption of cytotoxic lipid peroxidation products from food, known as MDA (malondialdehyde). (Link to RCT)

      Population:

       

      Intervention: Adding 200 mg (around half a WineSpan pill) molecularly identical red wine polyphenols powder to a meal before cooking + drinking a 200 mL (Medium-Large) glass of red wine with a meal.

       

      Control group A: No red wine intake with meal and no red wine polyphenols used

       

      Control group B: Drinking a glass of wine only with the meal, no red wine polyphenols used.

       

      Outcomes: Reduced plasma MDA levels after eating by 100% on average.

       

      Interpretation: Ingesting a WineSpan pill with a meal theoretically works in the same way as adding it to food during the cooking process - by stopping absorption of any created lipid peroxides in the food. If you don't want to drink red wine with the meal either, its likely that just taking the WineSpan pill with the meal alone will reduce MDA a lot. MDA in the body is cytotoxic, i.e. it kills cells and accelerates the aging process.

        Relevance to WineSpan: Here we can see it is not the alcohol component of red wine that is necessary for the benefits, and that adding the powder form enhances the benefits of alcoholic red wine.
         
        Additionally this trial of dealcoholised red wine will have used near identical polyphenol content to WineSpan - taking into account the minor variation in polyphenol profile between red wines.

        Clinical Trial #4: Alcoholic red wine

        Alcoholic red wine prevented 100% of the rise in dangerous oxidised LDL cholesterol in a broad range of people. This is unlikely to be due to the alcohol content, as White wine showed 0% prevention in the rise of oxLDL.

        250 mL of red wine with a meal prevented 100% of the increase in dangerous oxidised LDL, a RCT in healthy people, that don't consume more than 2 cups of flavonoid-rich beverages, such as tea, herb tea, coffee, cocoa, and fruit juice per day (Link to RCT #1)

         

        Red wine prevented 100% of the increase in dangerous oxidised LDL in all adults after a Mediterranean or high fat meal, and reduced oxidised LDL below baseline - white wine had no effect. Participants were a broad range of healthy adults on a normal polyphenol diet (Link to RCT #2)

          Relevance to WineSpan: Here we can see it is not the alcohol component of white wine NOR the polyphenols of white wine that is providing the benefits. Hence it is red wine that is optimal for this marker, not white wine.
           
          Additionally this trial of red wine will have used near identical polyphenol content to WineSpan - taking into account the minor variation in polyphenol profile between red wines.

          Randomised clinical trials on alcoholic red wine outperforming white wine

          Clinical trial #5: Red wine increases protective glutathione peroxidase gene expression by 10x when taken with a Mediterranean or high fat meal, whilst white wine has no effect (Link to RCT)

           

          Clinical trial #6: Red wine, but not white wine, raised good cholesterol (HDL-C) by 5 mg/dL in women (but not men), and Lp(a) by 0.1g/L (Link to RCT)

           

          Relevance to WineSpan: Here we can see it is not the alcohol component of white wine NOR the polyphenols of white wine that is providing the benefits. Hence it is red wine that is optimal for this marker, not white wine.
           
          Additionally this trial of red wine will have used near identical polyphenol content to WineSpan - taking into account the minor variation in polyphenol profile between red wines.

          However, one RCT has shown white wine to reduce inflammation (CRP blood test) in healthy people

          White wine reduced inflammation in healthy volunteers (CRP reduced from 0.26 md/dL to 0.19 mg/dL) and even more in people with chronic kidney disease (0.53 mg/dL to 0.34 mg/dL) (Link to RCT)

          *Red wine was not tested in this study

        • FAQ

          Is there anything I should notice once I start taking WineSpan?​

          WineSpan is designed to work beneath the surface, so its primary purpose is not to deliver surface-level results. Taking WineSpan is an investment in your long-term health of your cells, and you may not feel different despite the improvements happening inside your body. Everyone’s physiology is unique and results vary from person to person.

          Can't the potential benefits of alcoholic drinks come from the ethanol itself?

          Whilst ethanol may have some benefits in preventing blood clots (platelet aggregation), there is not much evidence for ethanol benefitting much else, and rather to the contrary. This would not fit with our current understanding of aging biology, as to yield a 2 year lifespan extension ethanol would be needing to have more evidence on aging biomarkers.

           

          Polyphenols, particularly red wine polyphenols, on the other hand have have a wealth of evidence including randomised controlled trials, that fits in with our understanding of improving biomarkers that are slowing the aging process, such as oxLDL, MDA, blood pressure and antioxidant enzymes.

          Why red not white or rose?

          When it comes to wine, red wine has around 6 - 7.5x higher polyphenol content per 100 mL than white wine (PubMed Reference 1) (PubMed Reference 2) and 5 times higher than rose wine (PubMed Reference).

          How is each serve equivalent to a large glass of French Wine? And how did you choose the dose of polyphenols per serving?

          WineSpan is based on the 10 studies on this page. The product is designed for each serving to

           

          1) exceed an above average polyphenol content glass of large red wine (>450 mg) as from the observational studies and

           

          2) reliably match or exceed all doses of red wine polyphenols used in red wine polyphenol randomised controlled trials (RCTs) (>540 mg).

           

          The average polyphenol content of red wine is 1800 mg/L as shown in PubMed Reference.

          How long should I take it for?

          WineSpan is designed to be taken for life. Either by itself or in addition to 0.5 - 1.5 units alcohol per day on average (recommended under 6 units total per day maximum to avoid binge drinking).

           

          The lifespan benefits of low dose alcohol intake in the prospective observational studies typically take 5+ years to start showing. In order for WineSpan to achieve its maximal benefit it should be taken for as young as possible.

          When do I take it?

          WineSpan should be taken with a meal, ideally supper, to replicate when red wine is normally taken.

           

          Alternatively part or all of the capsule can be emptied into the food before cooking, as a flavouring and to protect the food from molecular damage in the cooking process.

          Why are SOD, CAT and GPr important?

          CAT (Catalase)
          Grey hair is thought to be caused in part by a build up of hydrogen peroxide due to lack of catalase enzyme (catalase removes hydrogen peroxide). In a Chinese human grey hair study, in which Chinese men under age 25 experienced grey hair, it was found their hair catalase enzyme levels 30 x lower than in pigmented hair (Human Study). This association was also found in another human grey hair study (Human Study). However, catalase enhancers or red wine polyphenols have not been tested for grey hair repigmentation yet.
           
          Catalase when targeted to the mitochondria specifically slowed aging by 10% in wild type mice. It is not known if red wine polyphenols increase mitochondrial catalase levels, or just catalase in the nucleus, extracellular spaces or peroxisomes (these are the other common places where catalase resides). (Wild type mouse lifespan study).
           
          Low catalase levels are associated with causing sarcopenia, low muscle mass and strength in the elderly. (Rat Study)
           
          Catalase brain cell levels decline by 60% in age 65 human equivalent mice and rats, from age 18 human equivalent mice and rats. (Rat and mouse study). Arterial catalase activity levels in wild type mice were 50% lower at age 65 equivalent versus teenage years (Wild type mouse study)
           
          SOD (Superoxide dismutase)
          The role of SOD activity in aging is not clear. SOD is made up of SOD 1, 2 and 3. SOD1 mutations or dysfunctions that reduce its efficacy are linked to both familial and sporadic onset ALS (Lou Gherig's or Steven Hawking's disease). SOD enzyme activity is upregulated by the body naturally during times of stress - such as in late night or shift work, Alzheimer's disease or sarcopenia (Rat Study), but one theory is that upregulating it in advance of experiencing the stress allows the body to respond more quickly and achieve better outcomes. We could not find good human evidence of associated of RBC SOD activity levels and outcomes.
           
          Scientists that slowed the aging process in wild type mice using mitochondrial catalase hypothesise that enhancing SOD1 and 2, as well as catalase will enhance lifespan even more than enhancing catalase alone (Wild type mouse lifespan study).

          How did you calculate the adjusted antioxidant level gains to take into account the 2 day low polyphenol diet washout period?

          Compared to the baseline levels (2 days after starting a low polyphenol diet)

          • Glutathione reductase activity increased from 40 to 50 U/L, a 25% increase
          • Catalase activity increased from 9 to 16 nM/min/mL, an 80% increase
          • SOD (Superoxide dismutase) activity increased from 58 to 182 U/mL of RBC, over a 215% increase (more than tripled)
          • Lipids, liver markers, glutathione peroxidase, urate and GSH/GSSG ratio were unchanged
          As these antioxidant levels will drop consistently during the 2 days on a low polyphenol diet, we can take the average daily drop during the 7 study days and divide this by 2/7 to estimate how much the levels would have dropped in the first 2 days. We then compare this predicted baseline level in the control group to the results of the dealcoholised red wine group. This represents a worst case scenario, as half the control group will have been taking red wine the week before so may have elevated levels compared to controls that had just started the study 2 days previously. This would yield the following adjusted results
           
          We can be quite sure sure that it is the dealcoholised red wine causing this increase in antioxidant enzyme levels as the participants likely did not consume any other polyphenol rich foods. As the dealcoholised red wine increases the antioxidant levels above the baseline levels that were on the normal polyphenol diet levels, we can be somewhat sure that it will boost antioxidant levels in people already on a normal polyphenol diet.

          Does wine cause cancer?

          The risk of cancer from wine is due to the alcohol component not the polyphenols. So non-alcoholic beverages or WineSpan will carry no risk.

           

          In terms of alcoholic beverages, beer and spirits may increase risk at any level, however in low doses, wine may in fact reduce the risk of cancer more than not drinking at all. This is regards the risk of developing cancer in the first place and does not apply to post-cancer-diagnosis related outcomes such as cancer survival after diagnosis.

           

          To quote from one study "the data show that the carcinogenic effect of alcohol may be restricted to beer and spirits and may not be present in wine".

           

          50-90 mL wine/day may lower risk of breast cancer

          A meta-analysis of 26 observational studies all with multiple confounder adjustment found a 13% - 16% (95% confidence interval) reduction in breast cancer risk for those that drank 50 mL of wine per day, up to 90 mL of wine per day provided 95% chance of no increase risk of breast cancer. (Link to Meta Analysis)

           

          Wine likely has no effect on colorectal cancer risk

          A meta-analysis of 17 studies with 11000 colorectal cancer cases found no association for wine intake at any level (2019 meta analysis of cohort and case control studies)

           

          Red wine but not white wine might lower lung cancer risk

          A small case control study found red wine may reduce risk of lung cancer by at least 1%-2% per glass, whilst white wine may increase by 1%, there was no association with beer or spirits. These results were adjusted for cigarette pack count history. (Case control study)

           

          Wine likely no effect on oral cancer risk

          1-2 drinks of wine per day was associated with at least 25% increased risk of oral cancer diagnosis, however it is not clear how much beer these people drank and it was not adjusted for oral cancer causing HPV infection. I.e. they could have just been drinking a lot of beer, or had a higher incidence of oral HPV infection than the control group (Case control study)

           

          In one study with unclear 95% confidence intervals the median risk reduction in oral cancer was 45% in those drinking red wine of an unclear dose (Case control study)

           

          Up to 21 drinks of wine per week was not associated with upper digestive tract cancer and may reduce risk (Case control study), 1-2 drinks wine a day had no effect on oral cancer risk (Case control study), any amount of wine was not associated with oral cancer risk in the absence of other beer or spirit intake (Case control study)

          How does WineSpan differ from resveratrol?

          Resveratrol is just one polyphenol out of the 500+ polyphenols that naturally occur in red wine. Typically from 270 mg red wine polyphenols 0.1-1 mg of this is resveratrol. Hence is it around 0.1% to 0.3% of the polyphenols in red wine.

           

          The use of resveratrol does not seem evidence-based due to failure to provide clinically significant effect in all randomised clinical studies, non-randomised studies of interventions, pre-clinical lifespan studies and human epidemiological data.

        • Select your WineSpan Plan

          Alcohol free - Vegan - Vegetarian - 1 calorie per pill

          Molecularly identical polyphenols verified - Heavy metal tested - Bacterial contaminant tested

          Each pack of WineSpan pills provides polyphenols equivalent to

          • 1 large glass of French red wine per day

          • Over 12 bottles of French red wine per month

          • Reduces your calorie intake by 4000 calories per month

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        Products and Services do not provide medical advice. Do not make any changes to your health behaviours without consulting your licensed clinicians first. See the medical disclaimer within the terms and conditions.

         

        Oliver Zolman does not give medical advice. The contents on this site and his related Products & Services are for health informational purposes only, not medical advice.

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